Pompey will look to continue their positive run since the south-coast derby, with seven points collected from a possible nine in the Championship.
But how will John Mousinho go as he looks to build on those results, with three of the next four games at PO4?
Here’s how Blues writer Jordan Cross thinks Mousinho’s team will line up in the 12.30pm kick-off.
1. Jordan Cross' predicted Pompey line-up
Here's Jordan Cross' predicted Pompey line-up to face Millwall. | Jason Brown
.jpeg?trim=0,279,0,279&crop=&width=800)
2. GK: Nicolas Schmid
Beaten too easily at his near post for Wolves' goal on Tuesday, but made an important late stop in the 1-1 draw. Expected to continue. | Jason Brown
.jpeg?trim=0,278,0,278&crop=&width=800)
3. RB: Terry Devlin
Soaring return to the side with goalscoring contribution at Wolves. Brilliant battle with Zak Swanson developing, but Northern Ireland man deserves to keep his spot. | Jason Brown
4. CB Regan Poole
The best he's played for Pompey in the past couple of games, with the demand from John Mousinho to maintain those levels for a consistent period. | Jason Brown