Kenny Jackett’s side bid for back-to-back victories for the first time this season after Sunday’s 1-0 win at Gillingham.
It’s been a season of inconsistency so far for the Blues, who sit 13th in League One.
The Dons have a similar profile going into the game and are one place below Pompey.
Neilson is expecting a tough test against the Stadium MK outfit and he feels Jackett is assembling a side capable of promotion.
Portsmouth transfer news: Blues receive bids for former Luton and Millwall midfielder
'Is proving one hell of a signing.... A real livewire' - Portsmouth match ratings from 2-0 win at Cheltenham
Transfer gossip: Portsmouth eye raids for ex-Chelsea man and Charlton Athletic's former Wigan Athletic midfielder
Portsmouth boss Danny Cowley hails squad depth as tactical masterclass at Cheltenham pays off
14 splendid photos from Portsmouth’s 2-0 win against Cheltenham in sun-soaked League One encounter
The Scot said: ‘It’ll be a good one. They will have a great crowd, a good surface and a good team and hopefully it’ll be an enjoyable game.
‘He’s (Jackett) got great experience having managed a lot of teams at good levels.
‘He’s putting a team together who will be trying to get out of this league.
‘They’d kind of similar to us. They’ve stop-started with injuries and issues but I’m sure they will get sorted eventually.’