The star guest duo will head along to Bidmury Mead on Sunday, August 7 as the club marks its milestone occasion, having first launched back in 1872.
Off-spinner Panesar, who was part of the England squad which won the Ashes in Australia in 2010-11 - although he did not make an appearance in the series - and Clarke - himself featuring for his country in the Test and ODI formats - are part of a planned action-packed day to mark the Mariners reaching their 150th year.
Both the former international stars are scheduled to host a 'masterclass' coaching session with the club's newly formed colts section to kick things off.
The pair will also feature for the current Bedhampton Mariners side as they meet a Bedhampton Legends XI - made up of the club's leading former players - in a one-off match.
Those in attendance are then to be provided the opportunity to pick the brains of both Panesar and Clarke in a Q & A session to cap Bedhampton Mariners' big day.
Former Sussex, Essex and Northamptonshire spinner Panesar made 50 Test appearances for England, taking 167 wickets across a seven-year period and was handed his debut in the tour of India in Nagpur in March 2006.
All-rounder Clarke, 40, now retired, collected two England Test caps as well as featuring 20 times in ODI matches. He appeared for three different counties, Surrey, Derbyshire and Warwickshire, over a 19-year career.
Clarke amassed 11,387 runs and picked up 534 wickets in the 267 first-class matches he was involved in up until retiring in what was his third separate spell with Surrey at the end of last season.