The Blues have eighth fixtures throughout the month, facing League One promotion rivals including Peterborough, Ipswich, Fleetwood and Hull.
But Kenny Jackett’s full focus will be returning to the south coast with three points from Bloomfield Road.
The Pompey boss made five changes for Saturday’s 6-1 thrashing of King’s Lynn Town in the FA Cup.
He gave players such as Rasmus Nicolaisen, Cam Pring and Ben Close run-outs to rest some key players.
But with the Blues’ fringe men impressive in the routing, they’ll be hoping they’ve staked a claim to start against the Seasiders (7pm kick-off).
Jackett has to decide what, in his mind, is his best starting line-up to defeat Neil Critchley’s men.
We've predicted who’s likely to feature from the outset and be on the bench against Blackpool below...
5. Left-back - Lee Brown
Despite Cam Pring notching two assists on Saturday, Brown's nous will likely see him come back into the team. Will have the job of marking the rapid CJ Hamilton. Photo: Jason Brown
6. Right-midfield - Ryan Williams
Came back into the starting XI against King's Lynn after a groin setback. His attacking threat has proven fundamental for Pompey this season and has dovetailed superbly with Marcus Harness. Photo: Joe Pepler
7. Centre-midfield -Tom Naylor
Enjoying a prolific spell in front of goal, having scored three in as many games. He's arguably playing his best football during his time at PO4. Photo: Nigel Keene
8. Centre-midfield - Andy Cannon
Was deservedly given a breather on Saturday given his high-octane style. Formed an excellent partnership with Tom Naylor and has thrived since Pompey switched to a 4-4-2 formation. Photo: Joe Pepler