The Blues have eighth fixtures throughout the month, facing League One promotion rivals including Peterborough, Ipswich, Fleetwood and Hull.
But Kenny Jackett’s full focus will be returning to the south coast with three points from Bloomfield Road.
The Pompey boss made five changes for Saturday’s 6-1 thrashing of King’s Lynn Town in the FA Cup.
He gave players such as Rasmus Nicolaisen, Cam Pring and Ben Close run-outs to rest some key players.
But with the Blues’ fringe men impressive in the routing, they’ll be hoping they’ve staked a claim to start against the Seasiders (7pm kick-off).
Jackett has to decide what, in his mind, is his best starting line-up to defeat Neil Critchley’s men.
We've predicted who’s likely to feature from the outset and be on the bench against Blackpool below...
9. Left-midfield - Ronan Curtis
Appears well and truely over his blip at the start of the season. Already netted eight times this season and returns to the ground where he bagged his first Blues goals. Photo: PinPeP
10. Striker - Marcus Harness
With Ryan Williams back fit, it could see the ex-Burton man reinstated in a more advanced role where he's revelled in this season. Plundered eight goals in just 19 games to date. Photo: Daniel Chesterton
11. Striker - John Marquis
Pompey have been getting the best out of the marksman this season and he'll be looking to extend his lead as League One's top scorer. Photo: Joe Pepler
12. Sub 1 - Alex Bass
Was handed an outing in the Cup on Saturday and made a couple of decent saves. However, he'll likely be back to the bench tonight. Photo: Joe Pepler