The Blues have eighth fixtures throughout the month, facing League One promotion rivals including Peterborough, Ipswich, Fleetwood and Hull.
But Kenny Jackett’s full focus will be returning to the south coast with three points from Bloomfield Road.
The Pompey boss made five changes for Saturday’s 6-1 thrashing of King’s Lynn Town in the FA Cup.
He gave players such as Rasmus Nicolaisen, Cam Pring and Ben Close run-outs to rest some key players.
But with the Blues’ fringe men impressive in the routing, they’ll be hoping they’ve staked a claim to start against the Seasiders (7pm kick-off).
Jackett has to decide what, in his mind, is his best starting line-up to defeat Neil Critchley’s men.
We've predicted who’s likely to feature from the outset and be on the bench against Blackpool below...
13. Sub 2 - Rasmus Nicolaisen
Has admitted he'd be prepared to leave Pompey in January if he doesn't start playing regularly. However, he's found it difficult to disloge either Jack Whatmough and Sean Raggett when they've both been fit. Photo: Nigel Keene
14. Sub 3 - Cam Pring
Had a good outing against King's Lynn but may not be enough to keep Lee Brown out of the team. Photo: Daniel Chesterton
15. Sub 4 - Ben Close
The midfielder's composed passing caught the eye against the Linnets but he's unlikely to retain his starting spot. Photo: Jason Brown
16. Sub 5 - Bryn Morris
Been a regular off the bench of late but still awaits another starting opportunity. Photo: Joe Pepler