After suffering a 2-1 loss at Doncaster on Tuesday, the boss needs to find a way of remedying the Blues’ faltering League One promotion bid.
A top-two finish is looking more and more unlikely, with Pompey now facing a battle to cement a play-off spot.
Jackett's side not only need to deliver three points against the relegation-threatened Cobblers but deliver a performance that can prove the fillip for a big push in the business end of the season.
The Pompey manager will surely make changes from the loss to Donny, with teenager Haji Mnoga likely to be taken out of the side.
The Blues are hopeful James Bolton will be back fit while Michael Jacobs is also back in training.
Here’s how we think the visitors will line-up at Sixfields...
13. Sub 2 - James Bolton
Perhaps might not be fit enough and Kenny Jackett could want to save him for big games with Sunderland and Peterborough coming up if Callum Johnson remainds absent. Photo: Joe Pepler
14. Sub 3 - Lee Brown
Won't be a massive shock if he starts but Kenny Jackett may look for the attack-minded Charlie Daniels to feature instead. Photo: Joe Pepler
15. Sub 4 - Harvey White
The Spurs loanee has done well when starting the past three games but Pompey may look for something different. Photo: Jason Brown
16. Sub 5 - Marcus Harness
The winger is badly out of form and needs a bit of respite from the team. Photo: Daniel Chesterton