After suffering a 2-1 loss at Doncaster on Tuesday, the boss needs to find a way of remedying the Blues’ faltering League One promotion bid.
A top-two finish is looking more and more unlikely, with Pompey now facing a battle to cement a play-off spot.
Jackett's side not only need to deliver three points against the relegation-threatened Cobblers but deliver a performance that can prove the fillip for a big push in the business end of the season.
The Pompey manager will surely make changes from the loss to Donny, with teenager Haji Mnoga likely to be taken out of the side.
The Blues are hopeful James Bolton will be back fit while Michael Jacobs is also back in training.
Here’s how we think the visitors will line-up at Sixfields...
17. Sub 6 - Michael Jacobs
Having the cultured winger back fit is a huge boost. Photo: Joe Pepler
18. Sub 7 - Ellis Harrison
It would be a surprise if the Welshman is left out of the match-day squad. That will mean, however, there'll be no place for Jordy Hiwula - which will no doubt be met by fan frustration. Photo: Joe Pepler