John Mousinho’s men are aiming to hit a 23-year second-tier high against a Stoke City side going very well themselves.
So how does Mousinho attack the game as Pompey sign off for the November international break?
Here’s how Blue writer Jordan Cross thinks he will go.
9. RW: Adrian Segecic
Really extreme performances in past two games. Ineffective and hauled off at the break at Burnley, but full of energy on Tuesday night - more of the latter needed. | Jason Brown
10. CAM Odin Bailey
Really impressive full debut Tuesday, would be really harsh to take out Bailey. Segecic central and Kamara wide or Adams in the 10 are alternatives. | Jason Brown
11. LW Ryan Kavuma-McQueen
Chelsea loanee is fresh after being rested on Tuesday. | Jason Brown
12. CF Tyrese Shade
Waddingham or Shade the options to replace Marezi. We're leaning towards Shade with the Aussie pepping things up. | Jason Brown