Terry Devlin’s suspension for his red card handball at Sheffield United guarantees at least one change, as the Northern Ireland man serves a one-game suspension.
There are many other players whose continuing involvement will be under the microscope, after the weak 3-0 loss at Bramall Lane.
Here’s how Pompey writer Jordan Cross think John Mousinho will go, as his side look to avoid falling into the Championship relegation places.
17. Sub 5 Mark Kosznovszky
Ate up the yards last weekend against Millwall but pretty ineffective on Wednesday night. There's a very reasonable shout to start Marlon Pack or John Swift, so we've put the Hungarian on the bench. Photo: Simon Roe
18. Sub 6 Minhyeok Yang
Would have been close to start on Wednesday and could well get a runout if Lang is deemed not ready to feature from the outset. Photo: Graham Hunt
19. Sub 7 Florian Bianchini
Offered enthusiasm and energy against Millwall, but very little at Sheffield United. We've gone for the Frenchman dropping to the bench. | Paul Phelan/ProSportsImages
20. Sub 8 Conor Chaplin
A case of Segecic or Chaplin for the 10 role for this one, as the fans' favourite searches for that Pompey spark he and his team need. Photo: Stephen Flynn