Will the Blues boss ring the changes following such a poor performance in Wales? Or will he give those who let him and the travelling Pompey fans down the chance to redeem themselves against Sheffield Wednesday?
Those are the key questions on everyone’s mind ahead of such an important game. However, the three injuries picked up in midweek, plus an already sizeable injury list, means Mousinho could be restricted in what he can do to put such a disappointing defeat to bed.
Nevertheless, changes can be expected. So here’s how we think the Blues could line up as Friday night football returns to Fratton Park.
5. Right-wing-back - Terry Devlin
The Northern Irishman was one of the few positives from Tuesday night's defeat at Cardiff. Came on at half-time for the injured Jordan Williams and showed the fight, determination and energy that many of those around him sadly lacked. For that along, he deserves to start against the Owls tonight. | National World
6. Centre-midfield 1 - Marlon Pack
The Pompey skipper has had his performances come under increasing scrutiny this season following Pompey's step-up to the Championship. There's been calls for John Mousinho to drop him, but with the Blues lacking experience in midfield, that's easier said than done. Like Poole, he'll be determined to remind the Fratton faithful what he can bring to the table against the Owls as he's given a vote of confidence. | Getty Images
7. Centre-midfield 2 - Andre Dozzell
The midfielder has been an unused substitute for the past five games. It might be considered harsh on Freddie Potts to put him on the bench for tonight's game but the way the midfield was overrun on Tuesday night suggest a change is needed. Dozzell's greater experience might prove handy, too. | National World
8. Left-wing back - Matt Ritchie
A bit of a wild-card entry here maybe but Ritchie showed grit and determination when brought on during the second half against Cardiff. Questions continue to be raised about Connor Ogilvie's Championship credentials and while the wing-back system doesn't suit Josh Muprhy's game, Ritchie is a viable alternative. | National World