The match is the first of four games in five at PO4, with form there looking increasingly key to hopes of Championship survival as the Blues struggle on the road.
There’s fitness and selection calls for John Mousinho’s men to consider at present - here’s how we think he’ll go against Michael Carrick’s men.
1. Pompey predicted line-up
Here's how we think the Blues will line up against Middlesbrough. | The News
2. GK Nicolas Schmid
Off night against Blackburn, certainly in terms of the first goal and distribution, but still has stacks of credit in the bank | National World
3. RB Zak Swanson
Really interesting dynamic at right-back with Terry Devlin and Jordan Williams, but Swanson seems to be first choice at present. | National World
4. CB Marlon Pack
Continuing to cop some perplexing flak, seemingly from those favouring Ryley Towler. Worth remembering the upturn in results since skipper moved to defence. | Getty Images Photo: Matt McNulty/Getty Images