The Blues are aiming to bounce back to winning ways after being held to a 2-2 draw at Plymouth Argyle on Monday evening.
It’s been Pompey’s home form that’s been hampering their League One promotion push so far, having lost to Charlton in their last game at PO4.
And Crewe travel to the south coast in good form, having defeated leaders Peterborough and last season’s play-off finalists Oxford United in their past two games.
Kenny Jackett has to weigh up his starting line-up that will best equipped to beat Alexandra.
He was Lee Brown back from a hamstring injury, while Ronan Curtis returns after being on duty with the Republic of Ireland.
So who could be given the nod by Jackett to feature from the outset, who’ll make the bench and who might be left out of the match-day squad.
Scroll down and click through the pages to see how we predict Pompey’s match-day squad to look...
17. Sub 6 - Jordy Hiwula
Another who should benefit from the change to five substitutions. Still awaiting his first League One start for Pompey. Photo: Joe Pepler
18. Sub 7 - Ellis Harrison
Made a good impact when he came on at the break at Plymouth. Will continue to push for a starting spot. Photo: Joe Pepler