The Blues are aiming to bounce back to winning ways after being held to a 2-2 draw at Plymouth Argyle on Monday evening.
It’s been Pompey’s home form that’s been hampering their League One promotion push so far, having lost to Charlton in their last game at PO4.
And Crewe travel to the south coast in good form, having defeated leaders Peterborough and last season’s play-off finalists Oxford United in their past two games.
Kenny Jackett has to weigh up his starting line-up that will best equipped to beat Alexandra.
He was Lee Brown back from a hamstring injury, while Ronan Curtis returns after being on duty with the Republic of Ireland.
So who could be given the nod by Jackett to feature from the outset, who’ll make the bench and who might be left out of the match-day squad.
Scroll down and click through the pages to see how we predict Pompey’s match-day squad to look...
13. Sub 2 - Rasmus Nicolaisen
Given a tough time at Plymouth, which resulted in his withdrawl at half-time. Likely to be given a breather. Photo: Joe Pepler
14. Sub 3 - Cam Pring
Kenny Jackett has to decide whether it's Pring or Haji Mnoga who's the other defender on the bench. Judging by earlier in the season, the Bristol City loanee may just get the nod. Photo: Joe Pepler
15. Sub 4 - Ben Close
Didn't quite take his chance at Plymouth when he was taken off at the interval. Photo: Joe Pepler
16. Sub 5 - Bryn Morris
Hasn't had a lot of chances lately but rule change to allow five subs could be to his benefit. Photo: Joe Pepler