The Blues will be aiming to take another promotion rivals’ scalp after wins earlier in the season at Lincoln and Sunderland.
Kenny Jackett’s men have already made the visit to Portman Road this term.
Last month, they clinched a 3-2 victory after extra-time in what was an exciting FA Cup first-round tie.
Pompey head to East Anglia in confident mood after beating Peterborough United 2-0 at Fratton Park last week.
And they also have Michael Jacobs back fit, having recovered from the knee injury he suffered at Sunderland in October.
But how will Jackett’s side line-up against the Tractor Boys?
Scroll down to see how we think will feature from the outset and be on the Blues’ bench.
5. Left-back - Lee Brown
Been one of Pompey's most consistent performers all season and the boo boys have gone quiet. Photo: Joe Pepler
6. Right-midfield Ryan Williams
The Aussie could start in a more central role but he's highly likely to start regardless. His pressing in last week's win over Peterborough was key, Photo: PinPep
7. Centre-midfield - Tom Naylor
Will surely fancy himself to continue his red-hot goalscoring and bagged against Ipswich in the FA Cup. Photo: Joe Pepler
8. Centre-midfield - Andy Cannon
Has become a key member of this Pompey side with his fizz and energy, Photo: PinPeP