The Blues will be aiming to take another promotion rivals’ scalp after wins earlier in the season at Lincoln and Sunderland.
Kenny Jackett’s men have already made the visit to Portman Road this term.
Last month, they clinched a 3-2 victory after extra-time in what was an exciting FA Cup first-round tie.
Pompey head to East Anglia in confident mood after beating Peterborough United 2-0 at Fratton Park last week.
And they also have Michael Jacobs back fit, having recovered from the knee injury he suffered at Sunderland in October.
But how will Jackett’s side line-up against the Tractor Boys?
Scroll down to see how we think will feature from the outset and be on the Blues’ bench.
9. Left-midfield - Ronan Curtis
This game looks too soon for Michael Jacobs to start, but he should provide the Irishman with strong competition and he won't want to lose his spot. Photo: Joe Pepler
10. Striker - Marcus Harness
He'll play where Kenny Jackett feels the ex-Burton man can get the ball most frequently. Been a talismanic presence in recent months. Photo: Joe Pepler
11. Striker - John Marquis
He's not scored in his past four games but hasn't had a lot of service and will hoping to put that right. Photo: Joe Pepler
12. Sub 1 - Alex Bass
Kept a clean sheet at Cheltenham on Tuesday but will be back to deputy duties. Photo: Joe Pepler