The Blues will be aiming to take another promotion rivals’ scalp after wins earlier in the season at Lincoln and Sunderland.
Kenny Jackett’s men have already made the visit to Portman Road this term.
Last month, they clinched a 3-2 victory after extra-time in what was an exciting FA Cup first-round tie.
Pompey head to East Anglia in confident mood after beating Peterborough United 2-0 at Fratton Park last week.
And they also have Michael Jacobs back fit, having recovered from the knee injury he suffered at Sunderland in October.
But how will Jackett’s side line-up against the Tractor Boys?
Scroll down to see how we think will feature from the outset and be on the Blues’ bench.
13. Sub 2 Rasmus Nicolaisen
The Dane's been frustrated with his game-time and could end his loan spell in January if his situation doesn't change. Photo: .
14. Sub 3 - Cam Pring
The Bristol City loanee has made 12 appearances this season but has been second-choice left-back in the league. Photo: Joe Pepler
15. Sub 4 - Ben Close
The midfielder put in a fine performance at Cheltenham on Tuesday and gave his manager a reminder of his talent. Photo: Joe Pepler
16. Sub 5 - Michael Jacobs
The winger should be fit enough to make the bench but is unlikely to be risked from the start. Gives Pompey a big boost ahead of the festive period. Photo: Joe Pepler