The 17-year-old was handed a tough second round assignment against world number 15 Dave Gilbert and suffered a comprehensive 4-0 defeat.
Wilson went into round two at Celtic Manor on the back of a stunning fightback victory over Welshman Duane Jones last night - clinching just a second ever win on the main tour.
But former World Championship semi-finalist Gilbert provided a level up in opponent for the Waterlooville Sports Bar-based potter.
The world number 15 made half-century breaks of 54 in the opening two frames to go 2-0 ahead.
And Wilson was unable to mount a rousing fightback like he did the night previous, with Gilbert claiming a comfortable 4-0 victory.