Terry Devlin’s suspension for his red card handball at Sheffield United guarantees at least one change, as the Northern Ireland man serves a one-game suspension.
There are many other players whose continuing involvement will be under the microscope, after the weak 3-0 loss at Bramall Lane.
Here’s how Pompey writer Jordan Cross think John Mousinho will go, as his side look to avoid falling into the Championship relegation places.
9. RW Callum Lang
Rested at Sheffield Wednesday, John Mousinho has a big call over how Callum Lang is deployed. Probably ready to do at least a half now, so Lang could well be introduced but he will be straining at the leash to start. Photo: Dan Istitene
10. ACM Adrian Segecic
Was from the most culpable player on Wednesday night, but withdrawn amid reshuffle with Pompey down to 10 men. Means he's definitely ready to go again. | The News
11. LW Josh Murphy
Switched flanks on Wednesday and crossing was uncharacteristically wayward. Will operate in his usual role on the left for Bristol City. | Getty Images
12. CF Colby Bishop
Was taken off around hour mark at Bramall Lane, which felt like an effort to keep Bishop fresh for tomorrow. | Paul Phelan/ProSportsImages