The Blues are aiming to bounce back to winning ways after being held to a 2-2 draw at Plymouth Argyle on Monday evening.
It’s been Pompey’s home form that’s been hampering their League One promotion push so far, having lost to Charlton in their last game at PO4.
And Crewe travel to the south coast in good form, having defeated leaders Peterborough and last season’s play-off finalists Oxford United in their past two games.
Kenny Jackett has to weigh up his starting line-up that will best equipped to beat Alexandra.
He was Lee Brown back from a hamstring injury, while Ronan Curtis returns after being on duty with the Republic of Ireland.
So who could be given the nod by Jackett to feature from the outset, who’ll make the bench and who might be left out of the match-day squad.
Scroll down and click through the pages to see how we predict Pompey’s match-day squad to look...
5. Left-back - Lee Brown
Back training after his hamstring problem. A player who Kenny Jackett has utmost trust in and is likely to come back into the line-up. Photo: Joe Pepler
6. Right-midfield - Marcus Harness
Could start on the right or up front depending on where Kenny Jackett thinks he'll fit best. Will be full of confidence after his maiden international call-up. Photo: Graham Hunt
7. Centre-midfield - Tom Naylor
Scored in his past two appearances from outside the area. Photo: Graham Hunt
8. Centre-midfield - Andy Cannon
Such a key cog after the switch to 4-4-2. Photo: Graham Hunt