The Blues are aiming to bounce back to winning ways after being held to a 2-2 draw at Plymouth Argyle on Monday evening.
It’s been Pompey’s home form that’s been hampering their League One promotion push so far, having lost to Charlton in their last game at PO4.
And Crewe travel to the south coast in good form, having defeated leaders Peterborough and last season’s play-off finalists Oxford United in their past two games.
Kenny Jackett has to weigh up his starting line-up that will best equipped to beat Alexandra.
He was Lee Brown back from a hamstring injury, while Ronan Curtis returns after being on duty with the Republic of Ireland.
So who could be given the nod by Jackett to feature from the outset, who’ll make the bench and who might be left out of the match-day squad.
Scroll down and click through the pages to see how we predict Pompey’s match-day squad to look...
9. Left-midfield - Ronan Curtis
Available after making his first competitive start for the Republic of Ireland on Wednesday. Scored three goals in his past four games. Photo: Joe Pepler
10. Striker - Ryan Williams
Was subdued at Plymouth but was carrying a groin strain. Should be back to his best if he's completely over that setback. Photo: Graham Hunt
11. Striker - John Marquis
If Marquis is on target again, he'll have scored more league goals in 13 matches than he did for the entirety of last term. Photo: Pete Norton
