It’s just three days since the Blues dismissed league leaders Leeds at Fratton Park and will be looking to extend their impressive home form.
This has seen John Mousinho’s men lose just one of their last 12 games at PO4, with notable results coming against the Whites, Swansea, Bristol City and Coventry.
After facing Daniel Farke’s table-topping side on the weekend, the Pilgrims prop-up the Championship standings. Miron Muslic’s men sit six points away from safety after a run of five games without a win in the league.
In contrast, Pompey go into the game 12 points clear of Plymouth after an outstanding run of four victories in their previous five contests.
With another big crowd expected at Fratton Park this evening, we’ve taken a look at the injury news from both sides.
5. Muhamed Tijani - out
After returning to action in January, the 24-year-old is back on the casualty list after picking up a hamstring injury in late February. Tijani is set to remain absent for a few weeks. | Liverpool FC via Getty Images
6. Hayden Matthews - out
Matthews had been a revelation since his January switch from Sydney FC before the centre-back became the fifth Blues player to be ruled out for the remainder of the term after sustaining an ankle problem against QPR. | National World
7. Ibane Bowat - out
Despite a £500,000 move from Fulham in the summer, the centre-back has made just one appearance on the bench before being ruled out for the rest of the campaign with a knee issue. | Portsmouth FC
8. Paddy Lane - out
A knee injury sustained against Blackburn in January ruled the winger out for the rest of the season. | National World