It’s just three days since the Blues dismissed league leaders Leeds at Fratton Park and will be looking to extend their impressive home form.
This has seen John Mousinho’s men lose just one of their last 12 games at PO4, with notable results coming against the Whites, Swansea, Bristol City and Coventry.
After facing Daniel Farke’s table-topping side on the weekend, the Pilgrims prop-up the Championship standings. Miron Muslic’s men sit six points away from safety after a run of five games without a win in the league.
In contrast, Pompey go into the game 12 points clear of Plymouth after an outstanding run of four victories in their previous five contests.
With another big crowd expected at Fratton Park this evening, we’ve taken a look at the injury news from both sides.
Your next Pompey read: Portsmouth League One title winner dealt major injury blow during loan spell with Championship rivals
1. Pompey v Plymouth outs and doubts
The key injury news ahead of this evening's game against Plymouth. Pic: Graham Hunt/ProSportsImages | Graham Hunt/ProSportsImages
2. Adam Randell - out
The midfielder admitted a to misconduct charge by the FA after an incident against Cardiff last month and was given a three-game ban - meaning he will miss the trip to Fratton Park. | AFP via Getty Images
3. Conor Shaughnessy - out
There is growing hope the centre-back will return to action after the upcoming international break. The centre-back continues his recovery from an ankle injury and will of course be absent against Plymouth. Pic: Jason Brown/ProSportsImages | Jason Brown/ProSportsImages
4. Rob Atkinson - out
Similarly to Shaughnessy, the Blues will be hoping Atkinson will feature again after the international break as he continues his rehabilitation from a calf injury. | National World